Best Friend's Day: 12 of the Best Duos in Anime History
- The Wright Girl
- Jun 8
- 7 min read

Anime has a remarkable talent for showcasing friendships that go beyond what we typically see in real life. These duos become legends, embodying loyalty, trust, and shared adventures that resonate deeply with audiences across the globe. The relationships portrayed in these stories often reflect ideals of camaraderie and support, transcending the boundaries of ordinary friendships. They illustrate how bonds can be formed through trials and tribulations, highlighting the importance of having someone by your side during both joyous and challenging times. As we celebrate Best Friend's Day, let’s take a closer look at 12 iconic anime pairs that truly exemplify what it means to be the best of friends. Each of these pairs not only entertains us with their dynamic interactions and heartfelt moments but also teaches us valuable lessons about the power of friendship, sacrifice, and the deep connections that can form between individuals in the face of adversity.
Tanjiro & Nezuko - Demon Slayer (2019)
The relationship between Tanjiro Kamado and his sister Nezuko is one of the most touching portrayals of sibling love and friendship in anime history. Following the tragic events that lead to the death of their family and Nezuko's transformation into a demon, their bond becomes a beacon of hope and resilience. Tanjiro's unwavering determination to find a cure for Nezuko and protect her from harm underscores the lengths one will go for those they love. Nezuko, despite her demon nature, retains her humanity and fights alongside Tanjiro, showcasing her loyalty and bravery. Together, they navigate a perilous world filled with demons and danger, relying on each other for strength and comfort. Their journey is not just about survival; it is a testament to the enduring power of family and friendship, demonstrating that no matter the circumstances, the bonds we share can guide us through the darkest of times.
Gon & Killua - Hunter x Hunter (2011)
The friendship between Gon and Killua in the Hunter x Hunter series is undeniable. Despite their different backgrounds, their bond is built on deep trust and mutual respect. Gon Freecss, an optimistic boy on a quest to find his father, contrasts with Killua Zoldyck, who comes from a family of assassins. Their friendship allows Killua to explore his identity beyond his family's legacy. Throughout the series, their adventures highlight the joy of having someone who truly understands you. Their evolving friendship becomes a central theme, showcasing how they learn, grow, and face challenges together.
Ash & Pikachu - Pokémon (1997)
The adventurous duo of Ash and Pikachu perfectly captures the essence of loyalty! Since their first encounter, they've traveled through various regions, battling against incredible odds and forming lasting friendships with other trainers and Pokémon. Their journey not only showcases the thrill of adventure but also highlights pivotal moments, such as Ash's decision to trust Pikachu in key battles. Their unwavering support for each other inspires fans of all ages, reminding us that true friendship knows no limits.
Edward and Alphonse - Fullmetal Alchemist (2009)
Speaking of sibling bonds, the bond between Edward and Alphonse Elric is one of the most touching tales in anime. Their quest to restore their bodies after a tragic alchemical accident illustrates their unwavering love and determination. As they traverse a world filled with danger, their sacrifices become evident—Edward often puts his own safety at risk for Alphonse. This powerful narrative emphasizes the themes of loyalty and sacrifice, making their relationship unforgettable.
Kenpachi & Yachiru - Bleach (2004)

Kenpachi Zaraki and his loyal companion Yachiru Kusajishi are a prime example of an extraordinary friendship in the world of anime. Kenpachi, known for his immense strength and battle prowess, is often seen as a fearsome warrior. However, it is his relationship with Yachiru that adds depth to his character. Yachiru, with her playful demeanor and mischievous spirit, acts as both a guide and a source of inspiration for Kenpachi. Their bond is characterized by a unique blend of chaos and affection, as Yachiru’s unwavering support allows Kenpachi to embrace his true potential. Together, they embark on countless adventures, facing formidable foes and challenges, all while showcasing a deep-seated trust in one another that highlights the essence of true friendship.
Gohan & Piccolo - Dragon Ball Z (1989)

While they were not always close, Gohan and Piccolo’s relationship evolves dramatically after the Saiyan Saga. Initially, Piccolo is introduced as a formidable enemy, but as the series progresses, he becomes an essential mentor to Gohan. Their bond deepens through rigorous training sessions, where Gohan learns not only the art of combat but also the values of perseverance and determination. This transformation from adversaries to allies showcases a profound friendship built on mutual respect and understanding. Piccolo's protective nature towards Gohan, especially during critical battles, emphasizes the lengths to which friends will go to support one another. Their relationship serves as a testament to how friendships can blossom unexpectedly, leading to powerful connections that last a lifetime.
Fern & Frieren - Frieren's Journey & Beyond (2023)
This friendship is one we never thought we needed, but one we are glad to celebrate today. The dynamic between Fern and Frieren is unique, as it highlights the complexities of understanding emotions and the importance of communication in friendships. Despite Frieren's inability to grasp the intricate feelings of Fern, she consistently makes attempts to mend and strengthen their friendship, showcasing her commitment. Their journey together is filled with moments of both humor and heartfelt sincerity, reminding us that friendships can be a source of growth and learning. The contrast between Frieren's stoic demeanor and Fern's emotional depth creates a rich narrative that explores the nuances of companionship and the efforts required to maintain it, even when misunderstandings arise.
Luffy & Zoro - One Piece (1999)
The friendship between Luffy and Zoro is a cornerstone of the beloved series "One Piece." Their bond is characterized by their aspirations to become something bigger than themselves. Luffy, the carefree captain who aspires to be the pirate king, and Zoro, the steadfast swordsman who aspires to be the greatest swordsman of all time, embody the essence of teamwork and trust. This duo faces countless challenges together, from battling formidable foes to navigating treacherous seas, all while fostering a deep mutual respect. Zoro's unwavering loyalty to Luffy, even in the face of impossible odds, showcases the strength of their friendship. Their relationship is a perfect example of how friends can inspire each other to overcome their limits and pursue their dreams, making them an iconic pair in the anime world.
Tamaki & Kyoya - Ouran High School Host Club (2008)

To this day, the friendship between Tamaki and Kyoya stands as a testament to the uniqueness of their bond. Their dynamic is filled with humor and warmth, showcasing the odd yet endearing mothering ability that Kyoya exhibits towards Tamaki. This relationship is not just about playful banter; it also highlights the deeper understanding they have of each other’s strengths and weaknesses. Kyoya’s pragmatic approach often balances Tamaki’s exuberant personality, creating a harmonious friendship that thrives on their differences. Their interactions are not only entertaining but also reveal the importance of having a friend who can both challenge and support you, making their friendship truly relatable and memorable.
Natsu & Happy - Fairy Tail (2009)

The inseparable duo of Natsu and Happy is a shining example of loyalty and friendship in "Fairy Tail." Their relationship is built on unwavering support for one another. Happy, the flying blue cat, is not just Natsu’s companion but also his moral compass, often encouraging him to think before acting. Together, they embark on numerous quests, facing powerful foes and overcoming obstacles that test their bond. Their friendship exemplifies the idea that true friends are there for each other through thick and thin, providing encouragement and strength when it matters most. The light-hearted moments they share, combined with their fierce loyalty, make them one of the most beloved pairs in anime history.
Spike & Jet - Cowboy Bebop (1998)

The friendship between Spike and Jet in "Cowboy Bebop" is one marked by a deep understanding and shared experiences. As bounty hunters, they navigate a world filled with danger and uncertainty, relying on each other's skills and instincts. Their relationship is characterized by mutual respect, as both characters bring unique strengths to the table. Spike's laid-back attitude contrasts sharply with Jet's more serious demeanor, creating a balance that enhances their partnership. Throughout their adventures, they confront their pasts and the challenges of their chosen lifestyle, which ultimately strengthens their bond. Their friendship reflects the complexities of adult relationships, where trust and camaraderie are essential for survival in a chaotic world.
Hyakkimaru & Dororo - Dororo (2019)

The relationship between Hyakkimaru and Dororo is a powerful exploration of friendship in the face of adversity. Hyakkimaru, who has been stripped of a human body in a pact made by his father, finds solace and companionship in Dororo, a street-smart orphan. Their journey together is filled with trials that test their resolve, yet through every challenge, they learn to rely on one another. Dororo’s unwavering support helps Hyakkiumaru regain not only his physical form but also his humanity. Their friendship is a powerful narrative of healing and acceptance, showcasing how bonds can form in the most unexpected circumstances. Together, they navigate a world filled with demons and danger, proving that true friendship can illuminate even the darkest paths.
Celebrating Lasting Bonds
Anime has provided us with countless examples of enduring friendships through these unforgettable duos. From the thrilling adventures of Ash and Pikachu to the comedic parental bond between Kyoya and Tamaki, each relationship imparts valuable lessons about loyalty, sacrifice, and understanding. On this Best Friend’s Day, we celebrate these remarkable pairs and the powerful bonds they embody.
As you reflect on your favorite anime friendships, think about how these characters inspire you to cherish and nurture your own connections. Just as they do, friendships help shape who we are in life. Let's honor friendships that withstand the test of time and adventure—Happy Best Friend's Day!
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